New research showing that it may be possible to control the mechanism that leads to the rapid build-up of the proteins which are a key hallmark of Alzheimer’s disease has been given a cautious welcome..
The study of amyloid plaques, published in the journal Nature Physics, was conducted by Cambridge University researchers.
Dr James Pickett, head of research at the Alzheimer’s Society, said of the findings: “Reducing the build-up of amyloid plaques in the brain, the hallmark of Alzheimer’s disease, is a key focus of several current clinical trials.
“However, there is an ongoing debate among scientists about which step in the process of amyloid plaque formation should be the target for drug treatments.
“The study brings more useful evidence to these discussions by using computer modelling to examine the interactions between amyloid proteins and predict what is happening in the brain of a person with Alzheimer’s when plaques are formed.
“The next step is for these predictions to be tested in living cells so that the information can usefully help in the design of more effective treatments to target amyloid.”
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