BREAKTHROUGH COULD HELP IN TREATMENT OF CANCER & ARTHRITIS

    BREAKTHROUGH COULD HELP IN TREATMENT OF CANCER & ARTHRITIS

    We really are what we eat – at least when it comes to our immune system, according to new research.

    Scientists have discovered how cells in our immune system ‘eat’ other cells and ‘sense’ the damage that needs repairing.

    Researchers say their findings will allow for greater understanding of how our immune systems is activated which will play a key role in designing therapies for illnesses including cancer and arthritis.

    Immune cells play essential roles in the maintenance and repair of our bodies. When we injure ourselves, immune cells mount a rapid inflammatory response to protect us against infection and help heal the damaged tissue.

    Lead researcher Dr Helen Weavers, of Bristol University, said: “While this immune response is beneficial for human health, many human diseases – including atheroscelerosis, cancer and arthritis – are caused or aggravated by an overzealous immune response.

    “A greater understanding of what activates the immune response is therefore crucial for the design of novel therapies to treat these inflammatory disorders.

    “Our study found that immune cells must first become ‘activated’ by eating a dying neighbouring cell before they are able to respond to wounds or infection. In this way, immune cells build a molecular memory of this meal, which shapes their inflammatory behaviour.”

    The research, published in the journal Cell, used fruit flies to study how a particular immune cell, the macrophage, becomes activated in order to respond to injury or infection.

    Using the fly allowed researchers to make time-lapse movies of the dynamic behaviour of the immune cells as they migrate within a living organism. It also allowed them to easily manipulate different genes and signalling pathways within the fly, to test which genes are important for immune cell behaviour.

    Using genetics, the researchers dissected the mechanism by which the molecular memory is generated within the immune cell. Ingestion of the dying cell activates signalling via a calcium flash, which leads to an increase in the amount of an important damage receptor Draper in the immune cell.

    High levels of the receptor enable the ‘primed’ immune cell to sense the damage signals that entice them towards a wound during inflammation. Without this priming, the cells are blind to wounds and infections.

    Professor Paul Martin said: “Our work has important implications for human health, given that the pathology of many human diseases is often caused by an inappropriate inflammatory response.

    “Understanding how one signal – in this case a dying cell – can influence the ability of an immune cell to respond to a subsequent signal is a major step towards finding novel ways to clinically manipulate immune cells away from sites of the body where they are causing the most damage.”

    Wellcome Trust Senior Research Fellow Professor Will Wood added: “Using flies to study human disease might seem at first glance to be a rather strange approach, but this is an exciting advance in our understanding of immune cell behaviour, and takes us a step closer to designing novel therapeutic ways to influence immune cell behaviour within patients in the clinic.”

      Tags:

      • Overseeing countless major stories that have spawned over a career more than three decades long, our editor Andrew became one of the UK’s youngest ever staff reporters when he landed a job on the Today newspaper during the mid-80s. With news in his veins and being the son of the great Daily Mirror journalist Syd Young, Andrew is now a director at news agency SWNS.

        • Show Comments (0)

        Your email address will not be published. Required fields are marked *

        comment *

        • name *

        • email *

        • website *

        This site uses Akismet to reduce spam. Learn how your comment data is processed.

        Ads

        You May Also Like

        drove wrong way up motorway

        CIDER GUZZLER DRIVES UP ROAD THE WRONG WAY, CRASHES AND AVOIDS JAIL

        A drink-driver miraculously walked away from this wreckage after smashing his car into a ...

        IGNORED WARNINGS BY CALL HANDLER COSTS PATIENT HER LIFE

        IGNORED WARNINGS BY CALL HANDLER COSTS PATIENT HER LIFE

        A woman suffering breathing difficulties would probably still be alive if a NHS call ...

        FAMILY CELEBRATES VICTORY FOR COMMON SENSE AFTER COUNCIL ALLOWS BELOVED TREEHOUSE TO STAY IN

        FAMILY CELEBRATES VICTORY FOR COMMON SENSE AFTER COUNCIL ALLOWS BELOVED TREEHOUSE TO STAY IN

        A killjoy council which tried to tear down a child’s treehouse despite NO complaints ...

        Login